Inhibition of NMDA receptors by agmatine is followed by GABA/glutamate balance in benzodiazepine withdrawal syndrome

Abstract Background Drug withdrawal syndrome occurs due to abrupt cessation of an addictive substance. Dependence diazepam can be manifested by which may include symptoms such as irritability, psychosis, sleep disturbance, seizures, mood and anxiety. Studies have described the therapeutic role agmatine in various neurological disorders depressive mood, learning deficits, anxiety, memory impairment, psychosis. Various studies also validated a putant neuromodulator revealed its mechanism action with other neurotransmitters. The study was designed reveal potentials benzodiazepine maintaining GABA/glutamate balance. aimed determine underlying at synaptic level using behavioral biochemical evaluations. Results Agmatine significantly enhanced locomotion open filed test decreased anxiety observed elevated plus maze ( p < 0.01). reduced scores along compulsive behaviors marble burying improved muscular strength decreasing latency fall inverted screen Moreover, established balance increasing GABA levels glutamate concentration Conclusion present reveals possible on NMDA receptor interneurons post neuron that lead during syndrome.